O'Brien-Tribble intermarriages
Generation The difference between line breeding and inbreeding is in the result!
1 Robert/Mary Tribble Hiram/Hanna Tribble Enoch O'Brien Nancy O'Brien married T. Shaw Thomas/Lucinda O'Brien George/Sarah O'Brien
2 Nancy married GW O'Brien Elizabeth married S. P O'Brien G.W. married N. Tribble (Elizabeth's aunt by marriage) Minerva married John E. John T.
2 Elizabeth married Theolopolis Shaw Widow of Samuel Stephen P. married E. Tribble
2 John E. married M. O'Brien Widow of Samuel
Above are families intermarrying without inbreeding; below was line breeding
2 John/Minerva Tribble John/Minerva Tribble John T/Mary O'Brien
3 Harriet V married E. O'Brien Harriet V. married E. O'Brien Elmer G. married H. Tribble

Also, note that Myrtle C. Hussong married  Gus Grimes O'Brien in 1902.   Myrtle was the daughter of Sarah E. O'Brien, daughter of George Washington O'Brien and Gus was George Washington O'Brien's third wife's son by a previous marriage.